Novel protein kinase C inhibitors: synthesis and PKC inhibition of β-substituted polythiophene derivatives

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

A series of beta-substituted polythiophene derivatives was synthesized through palladium-catalyzed coupling reaction. Their structure-protein kinase C (PKC) inhibitory activity relationship was studied. The carboxaldehyde and hydroxymethyl derivatives of alpha-terthiophene were potent PKC inhibitors (IC50 = 10(-7) M).

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