Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro.

Knowledge Graph

Similar Paper