Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

Guanidine-substituted imidazoles were prepared and evaluated as inhibitors of the three isoforms of nitric oxide synthase. These results identify a new 2-substituted imidazole as an isoform selective inhibitor and illustrate the possible importance of the L-arginine side chain in selective isoform recognition.

Knowledge Graph

Similar Paper