Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described.

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