Discovery of a new class of p38 kinase inhibitors

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

The MAP kinase p38 has been implicated in cytokine signaling, and its inhibitors are potentially useful for the treatment of arthritis and osteoporosis. Novel small-molecule inhibitors of p38 kinase were derived from a combinatorial chemistry effort and exhibit activity in the nanomolar range. Very steep structure-activity relationships are observed within this class.

DOI： 10.1016/s0960-894x(00)00270-5

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