Potent inhibitors of the MAP kinase p38

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-alpha and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

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