The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

This communication describes the synthesis and in vitro evaluation of a novel and potent series of phosphodiesterase type IV (PDE4) inhibitors. The compounds described represent conformationally constrained analogues of RP 73401, Piclamilast. Preliminary evidences of reduced side effects of II compared to standards are also reported.

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