Binding of Aminoglycoside Antibiotics with Modified A-site 16S rRNA Construct Containing Non-Nucleotide Linkers

Binding of Aminoglycoside Antibiotics with Modified A-site 16S rRNA Construct Containing Non-Nucleotide Linkers Enhanced binding of aminoglycoside dimers to a “dimerized” A-site 16S rRNA construct The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6′-N-acetyltransferase and the role of 6′-NH2 in antibacterial activity Novel synthesis and RNA-Binding properties of aminoglycoside dimers conjugated via a naphthalene diimide-based intercalator Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains Structural hybridization of three aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA Synthesis and Antimicrobial Evaluation of Amphiphilic Neamine Derivatives Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics:  C2‘ ‘ Ether Analogues of Paromomycin