Synthesis of substituted imidazopyrazines as ligands for the human somatostatin receptor subtype 5

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

A new preparation of trisubstituted imidazopyrazines and dihydroimidazopyrazines via parallel synthesis using aminoacids and bromoketones resulted in the discovery of non-peptidic sst5 selective agonists.

Knowledge Graph

Similar Paper

Synthesis of substituted imidazopyrazines as ligands for the human somatostatin receptor subtype 5
Bioorganic & Medicinal Chemistry Letters 2001.0
3-Thio-1,2,4-triazoles, novel somatostatin sst2/sst5 agonists
Bioorganic & Medicinal Chemistry Letters 2005.0
Novel non-peptide ligands for the somatostatin sst3 receptor
Bioorganic & Medicinal Chemistry Letters 2001.0
Identification of Potent Non-Peptide Somatostatin Antagonists with sst<sub>3</sub> Selectivity
Journal of Medicinal Chemistry 2001.0
Discovery of Iodinated Somatostatin Analogues Selective for hsst2 and hsst5 with Excellent Inhibition of Growth Hormone and Prolactin Release from Rat Pituitary Cells
Journal of Medicinal Chemistry 2005.0
N-Imidazolebenzyl-histidine Substitution in Somatostatin and in Its Octapeptide Analogue Modulates Receptor Selectivity and Function
Journal of Medicinal Chemistry 2011.0
Nonpeptide Somatostatin Agonists with sst<sub>4</sub> Selectivity:  Synthesis and Structure−Activity Relationships of Thioureas
Journal of Medicinal Chemistry 1998.0
A non-peptide ligand for the somatostatin receptor having a benzodiazepinone structure
Bioorganic &amp; Medicinal Chemistry Letters 1996.0
First tricyclic oximino derivatives as 5-HT3 ligands
Bioorganic &amp; Medicinal Chemistry Letters 2001.0
Synthesis and in Vitro Characterization of N-[5-(4,5-Dihydro-1H-imidazol-2-yl)- 2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and Its Enantiomers:  A Novel Selective α<sub>1A</sub> Receptor Agonist
Journal of Medicinal Chemistry 1996.0