Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors
Bioorganic & Medicinal Chemistry Letters
2003.0
Abstract
Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.