Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.

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