Structure-based design and synthesis of HIV-1 protease inhibitors employing β-d-mannopyranoside scaffolds

Structure-based design and synthesis of HIV-1 protease inhibitors employing β-d-mannopyranoside scaffolds Design and Synthesis of New PotentC₂-Symmetric HIV-1 Protease Inhibitors. Use of<scp>l</scp>-Mannaric Acid as a Peptidomimetic Scaffold Identification of constrained peptidomimetic chemotypes as HIV protease inhibitors Design of potential anti-HIV agents. 1. Mannosidase inhibitors Design, Synthesis, Protein−Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol: Improved Antiviral Activity in Cells Novel inhibitors of HIV protease Synthesis, Stability, Antiviral Activity, and Protease-Bound Structures of Substrate-Mimicking Constrained Macrocyclic Inhibitors of HIV-1 Protease Design and synthesis of highly potent HIV-1 protease inhibitors with novel isosorbide-derived P2 ligands Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2′ side chains