Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC)

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

A series of succinimide hydroxamic acids was prepared and evaluated in vitro for HDAC inhibition and tumor cell antiproliferation. While the original macrocyclic analogue 6 was quite potent in both assays, several appropriately substituted non-macrocyclic succinimides, such as 23, were equipotent.

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