Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

A number of naphthofuranones were synthesized and tested for COX-1 and COX-2 inhibition. Few of them were identified as selective COX-2 inhibitors. Structure-activity relationship studies within the series are discussed.

Knowledge Graph

Similar Paper

Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 2003.0
2,2-Dimethyl-4,5-diaryl-3(2 H )furanone derivatives as selective cyclo-oxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 2001.0
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 1999.0
Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 2000.0
Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 2001.0
2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 2003.0
3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors
Bioorganic & Medicinal Chemistry Letters 2004.0
2,3-Diarylpyran-4-ones: a new series of selective cyclooxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 2004.0
4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 2002.0
Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors
Bioorganic & Medicinal Chemistry 2010.0