4-Phenyl-4H-pyrans as IKCa channel blockers

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

4-Phenyl-4H-pyrans have been identified as potent and specific IK(Ca) channel blockers. Their synthesis and structure-activity relationships are described. A selected derivative, rac-11, reduces the infarct volume in a rat subdural hematoma model of traumatic brain injury after iv administration.

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