Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

Although thrombin has been extensively researched with many examples of potent and selective inhibitors, the key characteristics of oral bioavailability and long half-life have been elusive. We report here a novel series non-peptidic phenyl-based, highly potent, highly selective and orally bioavailable thrombin inhibitors using oxyguanidines as guanidine-mimetics.

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