Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

The design and syntheses of new fluoroquinolone antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro antibacterial activities and pharmacokinetic profiles.

Knowledge Graph

Similar Paper

Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines
Bioorganic & Medicinal Chemistry Letters 2007.0
Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships
Journal of Medicinal Chemistry 1990.0
Fluoronaphthyridines and -quinolones as antibacterial agents. 5. Synthesis and antimicrobial activity of chiral 1-tert-butyl-6-fluoro-7-substituted-naphthyridones
Journal of Medicinal Chemistry 1992.0
Methyloxime-substituted aminopyrrolidine: A new surrogate for 7-basic group of quinolone
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis and antibacterial activity of 1-(substituted pyrrolyl)-7-(substituted amino)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
Journal of Medicinal Chemistry 1992.0
Synthesis and structure-activity relationships of new 7-[3-(fluoromethyl)piperazinyl]- and -(fluorohomopiperazinyl)quinolone antibacterials
Journal of Medicinal Chemistry 1990.0
Novel quinolone derivatives as potent antibacterials
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones
Journal of Medicinal Chemistry 1990.0
Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents
Journal of Medicinal Chemistry 1987.0