Lysine and ornithine analogs of methotrexate as inhibitors of dihydrofolate reductase

Lysine and ornithine analogs of methotrexate as inhibitors of dihydrofolate reductase Analogs of methotrexate Methotrexate analogs. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogs containing a basic amino acid side chain Methotrexate analogs. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N.epsilon.-(haloacetyl)-L-lysine and N.delta.-(haloacetyl)-L-ornithine analogs and an acivicin analog of methotrexate Methotrexate analogs. 15. A methotrexate analogue designed for active-site-directed irreversible inactivation of dihydrofolate reductase Methotrexate analogs. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogs Synthesis and biological activity of methotrexate analogs with two acid groups and a hydrophobic aromatic ring in the side chain Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogs of aminopterin and methotrexate Methotrexate analogs. 33. N.delta.-Acyl-N.alpha.-(4-amino-4-deoxypteroyl)-L-ornithine derivatives. Synthesis and in vitro antitumor activity Syntheses and evaluation as antifolates of MTX analogs derived from 2,.omega.-diaminoalkanoic acids