Synthesis and evaluation of some stable multisubstrate adducts as inhibitors of catechol O-methyltransferase

Synthesis and evaluation of some stable multisubstrate adducts as inhibitors of catechol O-methyltransferase Multisubstrate adducts as potential inhibitors of S-adenosylmethionine dependent methylases: inhibition of indole N-methyltransferase by (5H-deoxyadenosyl)[3-(3-indolyl)propyl-1-yl]methylsulfonium and (5'-deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium salts Analogues of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5'-thioether linkage Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 10. Base- and amino acid modified analogs of S-aristeromycinyl-L-homocysteine Synthesis and evaluation of analogues of S-adenosyl-l-methionine, as inhibitors of the E. coli cyclopropane fatty acid synthase Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 7. Role of the ribosyl moiety in enzymatic binding of S-adenosyl-L-homocysteine and S-adenosyl-L-methionine Inhibitors of polyamine biosynthesis. 8. Irreversible inhibition of mammalian S-adenosyl-L-methionine decarboxylase by substrate analogs Development of rationally designed DNA N6 adenine methyltransferase inhibitors Isozyme-specific enzyme inhibitors. 11. (L-homocysteine)-ATP S-C5' covalent adducts as inhibitors of rat methionine adenosyltransferases Activation and inhibition of DNA methyltransferases by S-adenosyl-l-homocysteine analogues