Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists

Journal of Medicinal Chemistry
1981.0

Abstract

1,2,3,4-Tetrahydro[1]benzothieno[2,3-h]isoquinolines were prepared and evaluated as dopamine antagonists and for potential neuroleptic activity. These compounds, which are analogues of the dopamine agonist apomorphine (2) in which the C-7 methylene has been removed, were found to be dopamine antagonists by in vitro receptor binding studies. However, in vivo evaluation did not suggest potential antipsychotic activity.

Knowledge Graph

Similar Paper

Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists
Journal of Medicinal Chemistry 1981.0
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity
Journal of Medicinal Chemistry 1980.0
Aporphines. 21. Dopaminergic activity of aporphine and benzylisoquinoline derivatives. Synthesis of 8-hydroxyaporphines and 1-(hydroxybenzyl)-2-n-propyl-1,2,3,4-tetrahydroisoquinolines
Journal of Medicinal Chemistry 1977.0
6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics
Journal of Medicinal Chemistry 1980.0
Specific dopamine D-1 and DA1 properties of 4-(mono- and -dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline and its tetrahydrothieno[2,3c]pyridine analog
Journal of Medicinal Chemistry 1987.0
1-(2′-Bromobenzyl)-6,7-dihydroxy-N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D<sub>2</sub> Dopamine Receptors
Journal of Natural Products 2020.0
Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands
Journal of Medicinal Chemistry 1988.0
10-(Alkylamino)-4H-thieno[3,4-b][1,5]benzodiazepines. A novel class of potential neuroleptic agents
Journal of Medicinal Chemistry 1979.0
5-Chloro-2-phenyl-1-benzo[b]thiophene-3-alkanamines, potential antipsychotic agents
Journal of Medicinal Chemistry 1978.0
3,4-Dihydroxy- and 3,4-methylenedioxy- phenanthrene-type alkaloids with high selectivity for D2 dopamine receptor
Bioorganic &amp; Medicinal Chemistry Letters 2013.0