The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

The first carbohydrate-free aminoglycoside analogs bearing the 2-deoxystreptamine moiety were synthesized from asymmetrically protected 2-deoxystrepamine and subsequently demonstrated to have significant binding to the 16S A-site rRNA target and moderate functional activity.

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