Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is replaced by heterocycles.

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