Synthesis and Biological Evaluation of Novel C-4 Aziridine-Bearing Paclitaxel (Taxol) Analogs

Journal of Medicinal Chemistry
1995.0

Abstract

Three novel C-4 aziridine-bearing paclitaxel analogs, 3-5, have been synthesized during the course of our continuing effort at C-4 modification. The key step in the synthesis is the aziridine ring formation at the C-4 position via an intramolecular Mitsunobu reaction. The syntheses and the biological evaluation of these C-4 aziridine-containing derivatives are herein discussed.

Knowledge Graph

Similar Paper

Synthesis and Biological Evaluation of Novel C-4 Aziridine-Bearing Paclitaxel (Taxol) Analogs
Journal of Medicinal Chemistry 1995.0
Synthesis and biological evaluation of 4-Deacetoxy-1,7-dideoxy azetidine paclitaxel analogues
Bioorganic & Medicinal Chemistry Letters 2003.0
Novel C-4 paclitaxel (Taxol®) analogs: potent antitumor agents
Bioorganic & Medicinal Chemistry Letters 1995.0
Structure-activity relationships study at the 3′-N position of paclitaxel-part 1: Synthesis and biological evaluation of the 3′-(t)-butylaminocarbonyloxy bearing paclitaxel analogs
Bioorganic & Medicinal Chemistry Letters 1997.0
Structure–activity relationships study at the 3′-N position of paclitaxel. part 2: synthesis and biological evaluation of 3′-N-thiourea- and 3′-N-thiocarbamate-bearing paclitaxel analogues
Bioorganic & Medicinal Chemistry Letters 2000.0
Heteroaromatic Taxol Analogues: The Chemistry and Biological Activities of 3′-Furyl and 3′-Pyridyl Substituted Taxanes
Bioorganic & Medicinal Chemistry Letters 1994.0
Synthesis and bioactivity of a side chain bridged paclitaxel: A test of the T-Taxol conformation
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis of biologically active 2-benzoyl paclitaxel analogues
Bioorganic & Medicinal Chemistry Letters 1995.0
Synthesis of biologically active taxol analogs with modified phenylisoserine side chains
Journal of Medicinal Chemistry 1992.0
Structure-activity relationships of taxol®: synthesis and biological evaluation of C2 taxol analogs
Bioorganic & Medicinal Chemistry Letters 1994.0