Development of Orally Bioavailable Bicyclic Pyrazolones as Inhibitors of Tumor Necrosis Factor-α Production

Development of Orally Bioavailable Bicyclic Pyrazolones as Inhibitors of Tumor Necrosis Factor-α Production The development of new triazole based inhibitors of tumor necrosis factor-α (TNF-α) production The development of new bicyclic pyrazole-based cytokine synthesis inhibitors The development of monocyclic pyrazolone based cytokine synthesis inhibitors Synthesis and bioactivities of novel bicyclic thiophenes and 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-α (TNF-α) production Synthesis and structure–activity relationship of cyclopentenone oximes as novel inhibitors of the production of tumor necrosis factor-α Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b]pyridazine-3-sulfonamide’s as an inhibitor of TNF-α production From Imidazoles to Pyrimidines:  New Inhibitors of Cytokine Release Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: Part 1 Carbocyclic Nucleosides as Inhibitors of Human Tumor Necrosis Factor-α Production:  Effects of the Stereoisomers of (3-Hydroxycyclopentyl)adenines