The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors 4-Amino derivatives of the Hsp90 inhibitor CCT018159 Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design Crystal structures of human HSP90α-complexed with dihydroxyphenylpyrazoles Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3- d ]pyrimidines as potent Hsp90 inhibitors N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold Structure-based discovery of a new class of Hsp90 inhibitors Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90