Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design 4-Amino derivatives of the Hsp90 inhibitor CCT018159 Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90 Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone