The discovery of a selective, high affinity A2B adenosine receptor antagonist for the potential treatment of asthma

The discovery of a selective, high affinity A2B adenosine receptor antagonist for the potential treatment of asthma A 2B adenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives Novel 1,3-Disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) Xanthines:  High Affinity and Selective A_2BAdenosine Receptor Antagonists Novel non-xanthine antagonist of the A2B adenosine receptor: From HTS hit to lead structure Structure−Activity Relationships at Human and Rat A_2B Adenosine Receptors of Xanthine Derivatives Substituted at the 1-, 3-, 7-, and 8-Positions Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity 4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: Drug-like and non-xanthine based A2B adenosine receptor antagonists Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A_2BAdenosine Receptor Antagonists Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines (E)-1,3-Dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists