Discovery of the First Potent, Selective 5-Hydroxytryptamine_1D Receptor Antagonist

Discovery of the First Potent, Selective 5-Hydroxytryptamine_1D Receptor Antagonist Discovery of Potent, Orally Bioavailable, Selective 5-HT_1A/B/D Receptor Antagonists Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 5 Synthesis, Potency, and in Vivo Evaluation of 2-Piperazin-1-ylquinoline Analogues as Dual Serotonin Reuptake Inhibitors and Serotonin 5-HT_1AReceptor Antagonists Synthesis and serotonergic activity of arylpiperazide derivatives of serotonin: potent agonists for 5-HT1D receptors Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives Synthesis and 5-hydroxytryptamine antagonist activity of 2-[[2-(dimethylamino)ethyl]thio]-3-phenylquinoline and its analogs Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors Studies toward the Discovery of the Next Generation of Antidepressants. 3. Dual 5-HT_1Aand Serotonin Transporter Affinity within a Class ofN-Aryloxyethylindolylalkylamines