Conversion of the Potent δ-Opioid Agonist H-Dmt-Tic-NH-CH₂-Bid into δ-Opioid Antagonists by N-Benzimidazole Alkylation¹

Conversion of the Potent δ-Opioid Agonist H-Dmt-Tic-NH-CH₂-Bid into δ-Opioid Antagonists by N-Benzimidazole Alkylation¹ Potent δ-Opioid Receptor Agonists Containing the Dmt−Tic Pharmacophore Evolution of the Dmt-Tic Pharmacophore:  N-Terminal Methylated Derivatives with Extraordinary δ Opioid Antagonist Activity Evaluation of the Dmt−Tic Pharmacophore:  Conversion of a Potent δ-Opioid Receptor Antagonist into a Potent δ Agonist and Ligands with Mixed Properties Assessment of substitution in the second pharmacophore of Dmt-Tic analogues Transformation of μ-opioid receptor agonists into biologically potent μ-opioid receptor antagonists 3-(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)- N-alkyl-N-arylbenzamides:  Potent, Non-Peptidic Agonists of Both the μ and δ Opioid Receptors Effect of Lysine at C-Terminus of the Dmt-Tic Opioid Pharmacophore Studies on the structure–activity relationship of 2′,6′-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H–Dmt–NH–CH3 Piperazinyl benzamidines: Synthesis and affinity for the delta opioid receptor