Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity.

Knowledge Graph

Similar Paper

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase
Bioorganic & Medicinal Chemistry Letters 2006.0
The structure-based design and synthesis of selective inhibitors of trypanosoma cruzi dihydrofolate reductase
Bioorganic & Medicinal Chemistry Letters 1999.0
Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase
Journal of Medicinal Chemistry 2006.0
Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase
Bioorganic & Medicinal Chemistry 2013.0
Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents
Bioorganic & Medicinal Chemistry 2009.0
Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates
Bioorganic & Medicinal Chemistry 2009.0
Design, synthesis and biological evaluation of hybrid bioisoster derivatives of N-acylhydrazone and furoxan groups with potential and selective anti-Trypanosoma cruzi activity
European Journal of Medicinal Chemistry 2014.0
2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: Structural design, synthesis and pharmacological evaluation
European Journal of Medicinal Chemistry 2014.0
Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase
European Journal of Medicinal Chemistry 2018.0
Design, synthesis, molecular docking and biological evaluation of thiophen-2-iminothiazolidine derivatives for use against Trypanosoma cruzi
Bioorganic & Medicinal Chemistry 2016.0