ACandida albicansPetite Mutant Strain with Uncoupled Oxidative Phosphorylation OverexpressesMDR1and Has Diminished Susceptibility to Fluconazole and Voriconazole

Antimicrobial Agents and Chemotherapy
2007.0

Abstract

We showed that a Candida albicans petite mutant in which oxidative phosphorylation is uncoupled was eightfold more resistant to fluconazole and voriconazole than SC5314 but equally susceptible to ketoconazole, itraconazole, and amphotericin B. Strain P5 significantly overexpressed MDR1, which likely accounts for the decreased drug susceptibility.

Knowledge Graph

Similar Paper

ACandida albicansPetite Mutant Strain with Uncoupled Oxidative Phosphorylation OverexpressesMDR1and Has Diminished Susceptibility to Fluconazole and Voriconazole
Antimicrobial Agents and Chemotherapy 2007.0
A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14α-Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B
Antimicrobial Agents and Chemotherapy 2010.0
The Ssk1p Response Regulator and Chk1p Histidine Kinase Mutants of Candida albicans Are Hypersensitive to Fluconazole and Voriconazole
Antimicrobial Agents and Chemotherapy 2007.0
Relative Contributions of the Candida albicans ABC Transporters Cdr1p and Cdr2p to Clinical Azole Resistance
Antimicrobial Agents and Chemotherapy 2009.0
Hypersusceptibility to Azole Antifungals in a Clinical Isolate of Candida glabrata with Reduced Aerobic Growth
Antimicrobial Agents and Chemotherapy 2009.0
Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance
Antimicrobial Agents and Chemotherapy 2007.0
Antifungal Drug Susceptibility Profile of Pichia anomala Isolates from Patients Presenting with Nosocomial Fungemia
Antimicrobial Agents and Chemotherapy 2007.0
Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans
Antimicrobial Agents and Chemotherapy 2010.0
Enhanced Susceptibility to Antifungal Oligopeptides in Yeast Strains Overexpressing ABC Multidrug Efflux Pumps
Antimicrobial Agents and Chemotherapy 2008.0
Gain-of-Function Mutations in the Transcription Factor MRR1 Are Responsible for Overexpression of the MDR1 Efflux Pump in Fluconazole-Resistant Candida dubliniensis Strains
Antimicrobial Agents and Chemotherapy 2008.0