Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H(3) ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed.

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