Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities

European Journal of Medicinal Chemistry
2007.0

Abstract

New arylidene-thiazolidinediones (ATZDs) were synthesized and evaluated in the alloxan-induced hyperglycemia mice model. The molecular target taken into consideration is the nuclear PPAR-gamma whose crystallographic structure is available on the PDB database as 2PRG. Thus the hypoglycemic and hypolipidemic activities of compounds were compared with the result of their docking after removal of the co-crystallized ligand present in the 2PRG structure. Molecular modeling studies were carried out using the Autodock 3.0.5 and ADT 1.1 programs.

Knowledge Graph

Similar Paper

Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities
European Journal of Medicinal Chemistry 2007.0
Synthesis and anti-inflammatory activity of new arylidene-thiazolidine-2,4-diones as PPARγ ligands
Bioorganic & Medicinal Chemistry 2010.0
5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents
Bioorganic & Medicinal Chemistry Letters 2003.0
Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: Synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression
Bioorganic & Medicinal Chemistry Letters 2014.0
Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring
European Journal of Medicinal Chemistry 2013.0
The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones
Journal of Medicinal Chemistry 1996.0
5-Aryl thiazolidine-2,4-diones as selective PPARγ agonists
Bioorganic & Medicinal Chemistry Letters 2003.0
Design, synthesis, in silico molecular docking and biological evaluation of novel oxadiazole based thiazolidine-2,4-diones bis-heterocycles as PPAR-γ agonists
European Journal of Medicinal Chemistry 2014.0
Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents
Journal of Medicinal Chemistry 1992.0
Novel Euglycemic and Hypolipidemic Agents. 4. Pyridyl- and Quinolinyl-Containing Thiazolidinediones
Journal of Medicinal Chemistry 1999.0