High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity

High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase Inhibitors ofTrypanosoma cruziTrypanothione Reductase Revealed by Virtual Screening and Parallel Synthesis Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei , Trypanosoma cruzi and Leishmania donovani Exploiting the Drug-Activating Properties of a Novel Trypanosomal Nitroreductase Novel polyamine derivatives as potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial Drugs