Discovery of tertiary aminoacids as dual PPARα/γ agonists-I

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

A novel series of potent dual agonists of PPARalpha and PPARgamma, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure-activity relationships of this series of dual PPARalpha/gamma agonists are described.

Knowledge Graph

Similar Paper

Discovery of tertiary aminoacids as dual PPARα/γ agonists-I
Bioorganic & Medicinal Chemistry Letters 2007.0
Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists
Bioorganic & Medicinal Chemistry Letters 2006.0
Design, synthesis, and structure–activity relationship of carbamate-tethered aryl propanoic acids as novel PPARα/γ dual agonists
Bioorganic & Medicinal Chemistry Letters 2007.0
Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists
Bioorganic & Medicinal Chemistry Letters 2008.0
Design and Synthesis of α-Aryloxyphenylacetic Acid Derivatives:  A Novel Class of PPARα/γ Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity
Journal of Medicinal Chemistry 2005.0
Pyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
Bioorganic & Medicinal Chemistry Letters 2006.0
Pyridine-2-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
Bioorganic & Medicinal Chemistry Letters 2006.0
Discovery of a Novel Series of Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists for the Treatment of Type 2 Diabetes and Dyslipidemia
Journal of Medicinal Chemistry 2005.0
Aryloxazolidinediones: identification of potent orally active PPAR dual α/γ agonists
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and evaluation of a series of benzopyran derivatives as PPAR α/γ agonists
European Journal of Medicinal Chemistry 2008.0