Synthesis, biological evaluations, and tubulin binding poses of C-2α sulfur linked taxol analogues

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

In combination with chemical modifications, bioassays, and computational simulation techniques, C-2 benzoylthio, and benzylthio taxoids were synthesized, biologically evaluated, and their binding conformations rationalized, in order to probe the interaction of taxane molecule with beta-tubulin.

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