Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.

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