Identification of a potent new chemotype for the selective inhibition of PDE4

Identification of a potent new chemotype for the selective inhibition of PDE4 Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors Discovery of triazines as potent, selective and orally active PDE4 inhibitors Design and synthesis of 4,5,6,7‐tetrahydro‐1 H ‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors 8-Substituted Analogues of 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl- adenine: Highly Potent and Selective PDE4 Inhibitors Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors Novel Selective PDE4 Inhibitors. 2. Synthesis and Structure−Activity Relationships of 4-Aryl-Substituted cis-Tetra- and cis-Hexahydrophthalazinones Synthesis and structure–activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1- hi ]indoles: novel PDE4 inhibitors Rhodanine derivatives as novel inhibitors of PDE4 Phthalazine PDE4 inhibitors. Part 2: The synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives