Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9microM while azumamide A (1) showed only weak inhibition at 19microM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

Knowledge Graph

Similar Paper

Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells
Bioorganic & Medicinal Chemistry Letters 2008.0
Titelbild: Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge <i>Mycale izuensis</i> / Total Synthesis of Azumamides A and E (Angew. Chem. 45/2006)
Angewandte Chemie 2006.0
Synthesis and biological evaluation of N-(4-hydroxy-3-mercaptonaphthalen-1-yl)amides as inhibitors of angiogenesis and tumor growth
European Journal of Medicinal Chemistry 2013.0
The Marine Fungal Metabolite, AD0157, Inhibits Angiogenesis by Targeting the Akt Signaling Pathway
Marine Drugs 2014.0
Synthesis and biological evaluation of novel bisindolylmaleimides that inhibit vascular endothelial cell proliferation
Bioorganic &amp; Medicinal Chemistry Letters 2001.0
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity
Journal of Medicinal Chemistry 2021.0
Synthesis and antiangiogenic activity of 6-amido-2,4,5-trimethylpyridin-3-ols
Bioorganic &amp; Medicinal Chemistry Letters 2014.0
Synthesis, in vitro and in vivo preliminary evaluation of anti-angiogenic properties of some pyrroloazaflavones
Bioorganic &amp; Medicinal Chemistry 2011.0
Ageladine A: An Antiangiogenic Matrixmetalloproteinase Inhibitor from the Marine Sponge <i>Agelas </i><i>n</i><i>akamurai</i>
Journal of the American Chemical Society 2003.0
Azaspirene:  A Novel Angiogenesis Inhibitor Containing a 1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione Skeleton Produced by the Fungus <i>Neosartorya</i> sp.
Organic Letters 2002.0