The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor

The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor Discovery of a Potent and Novel Motilin Agonist Identification of small molecule agonists of the motilin receptor Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate 9-Dihydroerythromycin ethers as motilin agonists—Developing structure–activity relationships for potency and safety 9-Dihydroerythromycins as non-antibiotic motilin receptor agonists Discovery of TD-8954, a clinical stage 5-HT4 receptor agonist with gastrointestinal prokinetic properties Synthesis and 5-HT3 receptor agonist activity of arylureas derived from histamine. Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A Discovery of novel acetanilide derivatives as potent and selective β3-adrenergic receptor agonists