Synthesis and 5-HT3 receptor agonist activity of arylureas derived from histamine.

Synthesis and 5-HT3 receptor agonist activity of arylureas derived from histamine. Synthesis and Histamine H1 Receptor Agonist Activity of a Series of 2-Phenylhistamines, 2-Heteroarylhistamines, and Analogs Nα-alkylated derivatives of 2-phenylhistamines: Synthesis and in vitro activity of potent histamine H1-receptor agonists Benzylamine histamine H3 antagonists and serotonin reuptake inhibitors Structure−Activity Relationships for the Binding of Arylpiperazines and Arylbiguanides at 5-HT₃Serotonin Receptors Novel, Potent, and Selective Quinoxaline-Based 5-HT₃Receptor Ligands. 1. Further Structure−Activity Relationships and Pharmacological Characterization N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxo-acetamide: a high affinity 5-HT3 receptor partial agonist Novel Potent and Selective Central 5-HT₃ Receptor Ligands Provided with Different Intrinsic Efficacy. 1. Mapping the Central 5-HT₃ Receptor Binding Site by Arylpiperazine Derivatives Design of a potent 5-HT4 receptor agonist with nanomolar affinity Role of Hydrophobic Substituents on the Terminal Nitrogen of Histamine in Receptor Binding and Agonist Activity: Development of an Orally Active Histamine Type 3 Receptor Agonist and Evaluation of Its Antistress Activity in Mice