Effect of Calcineurin Inhibitors on Posaconazole Blood Levels as Measured by the MVista Microbiological Assay

Antimicrobial Agents and Chemotherapy
2008.0

Abstract

Calcineurin inhibitors may augment the effects of antifungal drugs in microbiological assays. We examined this interaction in a microbiological assay for posaconazole. No effect was observed. However, concurrent or recently discontinued treatment with other antifungal drugs caused false-positive results, emphasizing a limitation of microbiological assays for antifungal drug level measurement.

Knowledge Graph

Similar Paper

Effect of Calcineurin Inhibitors on Posaconazole Blood Levels as Measured by the MVista Microbiological Assay
Antimicrobial Agents and Chemotherapy 2008.0
In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes
Antimicrobial Agents and Chemotherapy 2009.0
In Vitro Interactions between Tacrolimus and Azoles against Candida albicans Determined by Different Methods
Antimicrobial Agents and Chemotherapy 2008.0
Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus
Antimicrobial Agents and Chemotherapy 2007.0
A calcineurin antifungal strategy with analogs of FK506
Bioorganic & Medicinal Chemistry Letters 2017.0
Targeting the Calcineurin Pathway Enhances Ergosterol Biosynthesis Inhibitors against Trichophyton mentagrophytes In Vitro and in a Human Skin Infection Model
Antimicrobial Agents and Chemotherapy 2007.0
Correlation of In Vitro Activity, Serum Levels, and In Vivo Efficacy of Posaconazole against Rhizopus microsporus in a Murine Disseminated Infection
Antimicrobial Agents and Chemotherapy 2009.0
Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole
Antimicrobial Agents and Chemotherapy 2010.0
In Vitro Activities of Eight Antifungal Drugs against 55 Clinical Isolates of Fonsecaea spp
Antimicrobial Agents and Chemotherapy 2010.0
Posaconazole Enhances the Activity of Amphotericin B against Aspergillus Hyphae In Vitro
Antimicrobial Agents and Chemotherapy 2007.0