Literature

Abstract

In a wide search program for new and efficient antimicrobial agents, a series of t(3)-isopropyl-r(2),r(6)-di-2¢-furanylpiperidin-4-one 1 and its derivatives 2–7 were synthesized; characterized by IR, 1 H NMR, 1 H-1 H COSY, 13C NMR, and mass and elemental analysis; and their antibacterial activity against Streptococcus faecalis, Bacillus subtilis, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa and antifungal activity against Candida-6, Candida albicans, Aspergillus niger, Candida-51 and Aspergillus flavus was evaluated. Compound 6 exerted potent in vitro antibacterial activity against B. subtilis while compound 6 exhibited in vitro antifungal activity against Candida-6.

DOI： 10.1007/s00044-006-0032-y

Synthesis, stereochemistry, and antimicrobial evaluation of t(3)-isopropyl-r(2), c(6)-di-2′-furanylpiperidin- 4-one and its derivatives

Medicinal Chemistry Research 2007.0

Synthesis and microbial evaluation of novel N(1)-Arilidene-N(2)-t(3)-methyl-r(2),c(6)-diaryl-piperidin-4-one azine derivatives

Medicinal Chemistry Research 2007.0

Synthesis and Antimicrobial Evaluation of Some t(3)-Alkyl and t(3),t(5)-Dimethyl-r(2),c(6)-DI-2′-Furfurylpiperidin-4-one and its Derivatives

Medicinal Chemistry Research 2005.0

Synthesis, stereochemistry and antimicrobial evaluation of t(3)-benzyl-r(2),c(6)-diarylpiperidin-4-one and its derivatives

European Journal of Medicinal Chemistry 2007.0

Synthesis and Microbiological Evaluation of Some N-Methyl Piperidone Oxime Ethers

Medicinal Chemistry Research 2005.0

Synthesis and Microbiological Evaluation of Novel [N-Acetyl-2,6-Diarylpiperidin-4-YL]-5-Spiro-4-Acetyl-2-(Acetylamino)-Δ2-1,3,4-Thiadiazolines