Synthesis and antimicrobial screening of novel 2,6-ditertiarybutylpiperidin-4-ones

Medicinal Chemistry Research
2012.0

Abstract

A new series of 2,6-ditertiarybutyl 4-piperidones were prepared from an aliphatic aldehyde not having an alpha hydrogen atom and their structures were confirmed by elemental and spectral data. These compounds were screened for antibacterial (Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia) and antifungal (Aspergillus niger and Trichoderma sp.) activities and found to be potentially active against bacteria and fungi.

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