Design, synthesis, and docking studies of novel telmisartan–glitazone hybrid analogs for the treatment of metabolic syndrome

Medicinal Chemistry Research
2009.0

Abstract

A novel hybrid class of telmisartan–rosiglitazone molecules was synthesized in an attempt to discover a dual peroxisome proliferator-activated receptor gamma (PPARc) agonist/angiotensin II antagonist for treatment for metabolic syndrome. Almost all the synthesized molecules showed moderate PPARc activity. However, none of the hybrid analogs showed binding affinity toward the AT1 receptor.

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