Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-0500 is also described.

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