Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii

Antimicrobial Agents and Chemotherapy
2009.0

Abstract

In this study, a chromosomally encoded putative drug efflux pump of the SMR family, named AbeS, from a multidrug-resistant strain of Acinetobacter baumannii was characterized to elucidate its role in antimicrobial resistance. Expression of the cloned abeS gene in hypersensitive Escherichia coli host KAM32 resulted in decreased susceptibility to various classes of antimicrobial agents, detergents, and dyes. Deletion of the abeS gene in A. baumannii confirmed its role in conferring resistance to these compounds.

Knowledge Graph

Similar Paper

Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii
Antimicrobial Agents and Chemotherapy 2009.0
CraA, a Major Facilitator Superfamily Efflux Pump Associated with Chloramphenicol Resistance in Acinetobacter baumannii
Antimicrobial Agents and Chemotherapy 2009.0
Role of the AheABC Efflux Pump in Aeromonas hydrophila Intrinsic Multidrug Resistance
Antimicrobial Agents and Chemotherapy 2008.0
Screening and Quantification of the Expression of Antibiotic Resistance Genes in Acinetobacter baumannii with a Microarray
Antimicrobial Agents and Chemotherapy 2010.0
Cloning, Nucleotide Sequencing, and Analysis of the AcrAB-TolC Efflux Pump of Enterobacter cloacae and Determination of Its Involvement in Antibiotic Resistance in a Clinical Isolate
Antimicrobial Agents and Chemotherapy 2007.0
AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in Acinetobacter baumannii
Antimicrobial Agents and Chemotherapy 2008.0
Klebsiella pneumoniae AcrAB Efflux Pump Contributes to Antimicrobial Resistance and Virulence
Antimicrobial Agents and Chemotherapy 2010.0
The Efflux Pump Inhibitor Reserpine Selects Multidrug-Resistant Streptococcus pneumoniae Strains That Overexpress the ABC Transporters PatA and PatB
Antimicrobial Agents and Chemotherapy 2008.0
Contribution of the CmeABC Efflux Pump to Macrolide and Tetracycline Resistance in Campylobacter jejuni
Antimicrobial Agents and Chemotherapy 2007.0
Correlation of Antimicrobial Resistance with β-Lactamases, the OmpA-Like Porin, and Efflux Pumps in Clinical Isolates of Acinetobacter baumannii Endemic to New York City
Antimicrobial Agents and Chemotherapy 2008.0