Role of the AheABC Efflux Pump in Aeromonas hydrophila Intrinsic Multidrug Resistance

Antimicrobial Agents and Chemotherapy
2008.0

Abstract

Gene inactivation and complementation experiments showed that the tripartite AheABC efflux pump of Aeromonas hydrophila extruded at least 13 substrates, including nine antibiotics. The use of phenylalanine-arginine-beta-naphthylamide (PAbetaN) revealed an additional system(s) contributing to intrinsic resistance. This is the first analysis of the role of multidrug efflux systems in Aeromonas spp.

Knowledge Graph

Similar Paper

Role of the AheABC Efflux Pump in Aeromonas hydrophila Intrinsic Multidrug Resistance
Antimicrobial Agents and Chemotherapy 2008.0
Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii
Antimicrobial Agents and Chemotherapy 2009.0
Contribution of the CmeABC Efflux Pump to Macrolide and Tetracycline Resistance in Campylobacter jejuni
Antimicrobial Agents and Chemotherapy 2007.0
The Efflux Pump Inhibitor Reserpine Selects Multidrug-Resistant Streptococcus pneumoniae Strains That Overexpress the ABC Transporters PatA and PatB
Antimicrobial Agents and Chemotherapy 2008.0
Klebsiella pneumoniae AcrAB Efflux Pump Contributes to Antimicrobial Resistance and Virulence
Antimicrobial Agents and Chemotherapy 2010.0
AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in Acinetobacter baumannii
Antimicrobial Agents and Chemotherapy 2008.0
Substrate Competition Studies Using Whole-Cell Accumulation Assays with the Major Tripartite Multidrug Efflux Pumps of Escherichia coli
Antimicrobial Agents and Chemotherapy 2007.0
Pseudomonas aeruginosa May Accumulate Drug Resistance Mechanisms without Losing Its Ability To Cause Bloodstream Infections
Antimicrobial Agents and Chemotherapy 2007.0
CraA, a Major Facilitator Superfamily Efflux Pump Associated with Chloramphenicol Resistance in Acinetobacter baumannii
Antimicrobial Agents and Chemotherapy 2009.0
The BpeAB-OprB Efflux Pump of Burkholderia pseudomallei 1026b Does Not Play a Role in Quorum Sensing, Virulence Factor Production, or Extrusion of Aminoglycosides but Is a Broad-Spectrum Drug Efflux System
Antimicrobial Agents and Chemotherapy 2010.0