Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics

Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics Fragment Based Design of New H₄Receptor−Ligands with Anti-inflammatory Properties in Vivo Discovery of Quinazolines as Histamine H₄Receptor Inverse Agonists Using a Scaffold Hopping Approach Synthesis and QSAR of Quinazoline Sulfonamides As Highly Potent Human Histamine H₄ Receptor Inverse Agonists Synthesis and structure–activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists 2,4-Diaminopyrimidines as histamine H4 receptor ligands—Scaffold optimization and pharmacological characterization Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H₄Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models Histamine H4 receptor agonists Alkyl derivatives of 1,3,5-triazine as histamine H4 receptor ligands 2,4-Diaminopyrimidines as dual ligands at the histamine H 1 and H 4 receptor—H 1 /H 4 -receptor selectivity