Coumarin–trioxane hybrids: Synthesis and evaluation as a new class of antimalarial scaffolds

Bioorganic & Medicinal Chemistry Letters
2012.0

Abstract

First synthesis of novel coumarin-trioxane hybrids is reported. The synthesis was achieved via condensation of β-hydroxyhydroperoxides with coumarinic-aldehydes in presence of p-toluenesulfonic acid in good yields and the novel hybrids were evaluated for their antimalarial activity both in vitro and in vivo.

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