Eco-friendly synthesis and antimicrobial activities of substituted-5-(1H-indol-3-yl)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives

Medicinal Chemistry Research
2014.0

Abstract

L-Tyrosine is an efficient catalyst for the condensation of substituted indole-3-aldehydes 1(a–d), Nmethyl indole-3-aldehydes 4(a–d), and N-ethyl indole-3 aldehydes 6(a–d) with meldrum's acid (2) containing a cyclic active methylene group to produce 3(a–d), 5(a–d), and 7(a–d), respectively, in water at room temperature for 30 min. The antimicrobial activities of 3(a–d), 5(a–d), and 7(a–d) have been studied.

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